PF3D7_0320600

Genome location: Pf3D7_03_v3:862,233..864,181(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	expressed	0.43	0.74
Schizont	expressed	0.14	0.90
Gametocyte	expressed	0.77	0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0320600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.608 | MFS: -3.221 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1217900)

Relative Growth Rate: 0.02 ± 0.05
Confidence: 7.25

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9NFA1

"Best" AlphaFill ligand hit: PC (phosphocholine, Local RMSD=2.97) with 5WP4 (Global RMSD=14.04)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_174998

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	4	5	8
disruptive	1	3	2	9
missense	1	3	2	9

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	13	3	9
disruptive	2	13	7	30
missense	1	8	7	19

PlasmoDB Total SNPs: 184

Non-coding: 177 | Synonymous: 7 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 132 | Molecular Weight (kDa): 16.144

UniProt ID(s): Q9NFA1

PDB ID(s): None

Isoelectric Point: 9.63

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095