Product Description: signal peptidase complex subunit 2
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: 3.4.21.89 (Signal peptidase I)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0005787 | signal peptidase complex |
| Function | GO:0004175 | endopeptidase activity |
| Function | GO:0005515 | protein binding |
| Process | GO:0045047 | protein targeting to ER |
| Process | GO:0015031 | protein transport |
| Process | GO:0006465 | signal peptide processing |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.07 | 0.97 |
| Trophozoite | expressed | 0.51 | 0.70 |
| Schizont | expressed | 0.29 | 0.80 |
| Gametocyte | expressed | 0.27 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0320700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.5 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1217800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q9NFA0
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.4.21.89 | Signal peptidase I | NEMSDSEDTAMG132cholateantipainL685,458rifampicinBAL0019193arylomycinlactacystindeoxycholate... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 10 | 7 | 10 |
| disruptive | 4 | 11 | 7 | 25 |
| missense | 4 | 11 | 6 | 22 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 23 | 9 | 15 |
| disruptive | 11 | 29 | 19 | 49 |
| missense | 8 | 23 | 17 | 29 |
PlasmoDB Total SNPs: 129
Non-coding: 123 | Synonymous: 1 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 179 | Molecular Weight (kDa): 21.012
UniProt ID(s): Q9NFA0
PDB ID(s): None
Isoelectric Point: 9.39
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR009582 | Signal peptidase complex subunit Spc2/SPCS2 |
| PFam | PF06703 | Signal peptidase complex subunit Spc2/SPCS2 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30127496 | Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmicreticulum translocation interactome for export to the erythrocyte. | Marapana DS, Dagley LF, ..., Cowman AF | 10.1038/s41564-018-0219-2 |
| 36810679 | Methylation of CENP-A/Cse4 on arginine 143 and lysine 131 regulates kinetochorestability in yeast | Tran Nguyen TM, Munhoven A, ..., Ehrenhofer-Murray AE | 10.1093/genetics/iyad028 |
| 37950911 | A role for beta-1,6- and beta-1,3-glucans in kinetochore function in Saccharomycescerevisiae | Kshirsagar R, Munhoven A, Tran Nguyen TM, Ehrenhofer-Murray AE | 10.1093/genetics/iyad195 |