Product Description: histone H2A.Z
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000785 | chromatin |
| Component | GO:0000786 | nucleosome |
| Component | GO:0005634 | nucleus |
| Function | GO:0003677 | DNA binding |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003682 | chromatin binding |
| Process | GO:0006333 | chromatin assembly or disassembly |
| Process | GO:0006325 | chromatin organization |
| Process | GO:0006342 | chromatin silencing |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.32 | 0.42 |
| Trophozoite | expressed | 1.42 | 0.36 |
| Schizont | expressed | 2.27 | 0.14 |
| Gametocyte | expressed | 0.85 | 0.55 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0320900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.16 | MFS: -3.448 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1217600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97320
"Best" AlphaFill ligand hit: BCN (bicine, Local RMSD=0.08) with 6AE8 (Global RMSD=1.38)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101774
Most Similar Human Ortholog: E5RJU1
TM-align score: 0.95 | RMSD: 0.43
Seq Identity: 0.78 | Length: 40 / 158
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000105968 | H2A.Z variant histone 2 |
| ENSG00000164032 | H2A.Z variant histone 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 12 | 3 | 8 |
| disruptive | 0 | 0 | 0 | 3 |
| missense | 0 | 0 | 0 | 3 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 22 | 8 | 8 |
| disruptive | 1 | 6 | 10 | 34 |
| missense | 0 | 1 | 9 | 28 |
PlasmoDB Total SNPs: 177
Non-coding: 172 | Synonymous: 5 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 158 | Molecular Weight (kDa): 16.453
UniProt ID(s): O97320
PDB ID(s): None
Isoelectric Point: 11.36
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002119 | Histone H2A |
| InterPro | IPR007125 | Histone H2A/H2B/H3 |
| InterPro | IPR009072 | Histone-fold |
| InterPro | IPR032454 | Histone H2A, C-terminal domain |
| InterPro | IPR032458 | Histone H2A conserved site |
| PFam | PF00125 | Histone H2A/H2B/H3 |
| PFam | PF16211 | Histone H2A, C-terminal domain |
| Superfamily | SSF47113 | Histone-fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 21187892 | H2A.Z demarcates intergenic regions of the plasmodium falciparum epigenome thatare dynamically marked by H3K9ac and H3K4me3. | Bartfai R, Hoeijmakers WA, ..., Stunnenberg HG | 10.1371/journal.ppat.1001223 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 23373537 | H2A.Z and H2B.Z double-variant nucleosomes define intergenic regions anddynamically occupy var gene promoters in the malaria parasite Plasmodiumfalciparum. | Petter M, Selvarajah SA, ..., Duffy MF | 10.1111/mmi.12154 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33225957 | Histone modifications associated with gene expression and genome accessibilityare dynamically enriched at Plasmodium falciparum regulatory sequences. | Tang J, Chisholm SA, ..., Duffy MF | 10.1186/s13072-020-00365-5 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 38106078 | Nucleic acid sequence contributes to remodeler-mediated targeting of histone H2A.Z | Converso C, Pierrakeas L, ..., Luk E | 10.1101/2023.12.06.570360 |
| 38366024 | Histone Variant H2A.Z and Linker Histone H1 Influence Chromosome Condensation inSaccharomyces cerevisiae | Rogers AM, Neri NR, Chigweshe L, Holmes SG | 10.1093/genetics/iyae022 |