PF3D7_0321300

Genome location: Pf3D7_03_v3:889,611..893,080(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	not expressed	0.16	0.90
Schizont	not expressed	0.24	0.84
Gametocyte	possibly expressed	0.58	0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0321300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.265 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97288

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532587

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	14	45	18	71
disruptive	42	169	94	215
missense	32	146	74	160

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	27	82	33	76
disruptive	96	368	161	331
missense	64	271	120	198

PlasmoDB Total SNPs: 231

Non-coding: 105 | Synonymous: 73 | Nonsynonymous: 53 | Stop Codon: 0

Protein Information

Protein Length: 916 | Molecular Weight (kDa): 111.918

UniProt ID(s): O97288

PDB ID(s): None

Isoelectric Point: 10.12

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095