Product Description: pseudo protein kinase 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 2.7.11.17 (Calcium/calmodulin-dependent protein kinase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0034399 | nuclear periphery |
| Component | GO:0005634 | nucleus |
| Function | GO:0004672 | protein kinase activity |
| Process | GO:0006468 | protein phosphorylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 0.99 |
| Trophozoite | not expressed | 0.01 | 0.99 |
| Schizont | expressed | 0.35 | 0.78 |
| Gametocyte | possibly expressed | 0.02 | 0.99 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0321400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.31 | MFS: -2.59 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1217100)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PY17X_1220300)
Modification: Tagged | RMgm-4709
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H482
"Best" AlphaFill ligand hit: ADN (adenosine, Local RMSD=0.54) with 4O0W (Global RMSD=4.33)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.7.11.17 | Ca2+/calmodulin-dependent protein kinase | NOADPGTPW13AIPEDTAEGTADTNBKN93KN62KN-93KN-62... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 27 | 10 | 23 |
| disruptive | 1 | 17 | 11 | 41 |
| missense | 1 | 17 | 11 | 34 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 44 | 13 | 27 |
| disruptive | 6 | 57 | 28 | 97 |
| missense | 6 | 47 | 23 | 50 |
PlasmoDB Total SNPs: 130
Non-coding: 115 | Synonymous: 13 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 319 | Molecular Weight (kDa): 38.016
UniProt ID(s): C0H482
PDB ID(s): None
Isoelectric Point: 6.5
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000719 | Protein kinase domain |
| InterPro | IPR011009 | Protein kinase-like domain superfamily |
| PFam | PF00069 | Protein kinase domain |
| Superfamily | SSF56112 | Protein kinase-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 29197418 | Tagging to endogenous genes of Plasmodium falciparum using CRISPR/Cas9. | Kuang D, Qiao J, ..., Dai X | 10.1186/s13071-017-2539-0 |
| 36967885 | Polyphosphate kinase 1 is involved in formation, the morphology andultramicrostructure of biofilm of Mycobacterium smegmatis and its survivabilityin macrophage | He C, Li B, ..., Shi T | 10.1016/j.heliyon.2023.e14513 |
| 38170746 | Polyphosphate kinase-1 regulates bacterial and host metabolic pathways involvedin pathogenesis of Mycobacterium tuberculosis | Chugh S, Tiwari P, ..., Singh R | 10.1073/pnas.2309664121 |
| 37574318 | [Effects of ppk1 deletion on the drug susceptibility of uropathogenic Escherichiacoli producing ESBLs] | Ou JY, Chen WS, ..., Shi YL | 10.3760/cma.j.cn112150-20220906-00876 |
| 36403711 | Exopolyphosphatases PPX1 and PPX2 from Mycobacterium tuberculosis regulatedormancy response and pathogenesis | Tiwari P, Gosain TP, ..., Singh R | 10.1016/j.micpath.2022.105885 |