About Gene List

PF3D7_0321700

Genome location: Pf3D7_03_v3:903,127..910,678(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.17 0.92
Trophozoite not expressed 0.70 0.64
Schizont not expressed 0.91 0.55
Gametocyte not expressed 0.77 0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0321700

Resistome Missense Mutations: D853N

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 6 (6 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.163 | MFS: -2.773 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1216800)

Modification: Disrupted | RMgm-3255

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97291

"Best" AlphaFill ligand hit: VIB (3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium, Local RMSD=0.15) with 4KYS (Global RMSD=26.60)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_157331

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 17 73 52 101
disruptive 144 294 123 369
missense 70 214 91 276

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 24 166 62 113
disruptive 222 601 246 575
missense 101 432 177 352

PlasmoDB Total SNPs: 376

Non-coding: 87 | Synonymous: 128 | Nonsynonymous: 161 | Stop Codon: 0

Protein Information

Protein Length: 1946 | Molecular Weight (kDa): 231.793

UniProt ID(s): O97291

PDB ID(s): None

Isoelectric Point: 5.27

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104