Product Description: cyclic amine resistance locus protein
SignalP Peptide: N/A
# Transmembrane Domains: 7
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005801 | cis-Golgi network |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0030176 | integral component of endoplasmic reticulum membrane |
| Process | GO:0035437 | maintenance of protein localization in endoplasmic reticulum |
| Process | GO:0042493 | response to drug |
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.55 | 0.74 |
| Trophozoite | expressed | 0.61 | 0.66 |
| Schizont | expressed | 0.48 | 0.72 |
| Gametocyte | expressed | 0.39 | 0.77 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0321900
Resistome Missense Mutations: M81I, L659F, Q821H, P822L, L830V, L833I, E834K, E834D, L1073Q, S1076N, S1076I, S1134R, L1142I
Resistome Compounds with Missense Mutations: BI-2536, GNF179/KAF179, GNF452, GNF707, MMV007564, MMV907364
Resistome # Samples with Disruptive Mutations: 17 (15 missense, 14 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.187 | MFS: -2.781 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1216600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H483
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101942
Most Similar Human Ortholog: Q6NXT6
TM-align score: 0.64 | RMSD: 2.42
Seq Identity: 0.27 | Length: 380 / 1283
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000169762 | transmembrane anterior posterior transformation 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 71 | 45 | 74 |
| disruptive | 37 | 142 | 104 | 202 |
| missense | 29 | 128 | 99 | 180 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 23 | 145 | 55 | 85 |
| disruptive | 63 | 316 | 167 | 351 |
| missense | 45 | 276 | 136 | 254 |
PlasmoDB Total SNPs: 365
Non-coding: 278 | Synonymous: 55 | Nonsynonymous: 32 | Stop Codon: 0
Protein Length: 1283 | Molecular Weight (kDa): 153.405
UniProt ID(s): C0H483
PDB ID(s): None
Isoelectric Point: 9.6
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR008010 | Tapt1 family |
| PFam | PF05346 | Tapt1 family |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 22096101 | Imaging of Plasmodium liver stages to drive next-generation antimalarial drugdiscovery. | Meister S, Plouffe DM, ..., Winzeler EA | 10.1126/science.1211936 |
| 27381290 | Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (Pf CARL)Confer Multidrug Resistance | LaMonte G, Lim MY, ..., Winzeler EA | 10.1128/mBio.00696-16 |
| 27642791 | UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistancegenes. | Lim MY, LaMonte G, ..., Bifani P | 10.1038/nmicrobiol.2016.166 |