Product Description: peptidyl-prolyl cis-trans isomerase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 5.2.1.8 (Peptidylprolyl isomerase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005829 | cytosol |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
| Function | GO:0016018 | cyclosporin A binding |
| Function | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| Process | GO:0006457 | protein folding |
| Process | GO:0000413 | protein peptidyl-prolyl isomerization |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 1.77 | 0.33 |
| Trophozoite | expressed | 2.51 | 0.14 |
| Schizont | expressed | 0.56 | 0.69 |
| Gametocyte | expressed | 0.97 | 0.55 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0322000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1216500)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1216500)
Modification: Disrupted | RMgm-3253
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q76NN7
"Best" AlphaFill ligand hit: LSA (saccharin, Local RMSD=0.05) with 4N1O (Global RMSD=0.88)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 5.2.1.8 | peptidylprolyl isomerase | ATPNEMSDSPCMBFK506QAEGPKAla-ProjugloneSer-ProGPI-1046RNase T1Rapamycin... |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P23284 | Peptidyl-prolyl cis-trans isomerase B | Homo sapiens | HOGENOM, OrthoDB | US8901295, F607Aryl 1-indanylketone, 3Aryl 1-indanylketone, 4US8901295, F428... |
| P45877 | Peptidyl-prolyl cis-trans isomerase C | Homo sapiens | HOGENOM, OrthoDB | CHEMBL2424822 |
| Q08752 | Peptidyl-prolyl cis-trans isomerase D | Homo sapiens | OrthoDB | Aryl 1-indanylketone, 1Aryl 1-indanylketone, 2US8901295, F428US8901295, F671... |
Ortholog Group (OrthoMCL): OG6_100528
Most Similar Human Ortholog: F8WE65
TM-align score: 0.99 | RMSD: 0.49
Seq Identity: 0.63 | Length: 120 / 171
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000108179 | peptidylprolyl isomerase F |
| ENSG00000196262 | peptidylprolyl isomerase A |
Protein Length: 171 | Molecular Weight (kDa): 18.953
PDB ID(s): None
Isoelectric Point: 8.04
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002130 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain |
| InterPro | IPR020892 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site |
| InterPro | IPR024936 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase |
| InterPro | IPR029000 | Cyclophilin-like domain superfamily |
| PFam | PF00160 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain |
| Superfamily | SSF50891 | Cyclophilin-like domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 5 | 13 | 8 |
| disruptive | 2 | 5 | 1 | 9 |
| missense | 2 | 5 | 1 | 8 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 27 | 6 | 8 |
| disruptive | 4 | 22 | 7 | 28 |
| missense | 3 | 17 | 5 | 20 |
PlasmoDB Total SNPs: 34
Non-coding: 29 | Synonymous: 4 | Nonsynonymous: 1 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9716503 | Detailed characterization of a cyclophilin from the human malaria parasitePlasmodium falciparum. | Berriman M, Fairlamb AH | 10.1042/bj3340437 |
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |