PF3D7_0322200

Genome location: Pf3D7_03_v3:933,188..937,006(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020007	apical complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.03	0.98
Schizont	not expressed	0.06	0.96
Gametocyte	not expressed	0.38	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0322200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.693 | MFS: -0.397 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1216300)

Relative Growth Rate: 1.03 ± 0.17
Confidence: 4.96

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1216300)

Modification: Tagged | RMgm-4954

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97294

"Best" AlphaFill ligand hit: ABH (2(s)-amino-6-boronohexanoic acid, Local RMSD=0.71) with 3MMR (Global RMSD=13.68)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533529

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	36	24	57
disruptive	17	81	58	127
missense	17	80	57	117

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	78	41	55
disruptive	32	206	91	148
missense	29	180	78	110

PlasmoDB Total SNPs: 234

Non-coding: 170 | Synonymous: 43 | Nonsynonymous: 21 | Stop Codon: 0

Protein Information

Protein Length: 753 | Molecular Weight (kDa): 91.02

UniProt ID(s): O97294

PDB ID(s): None

Isoelectric Point: 9.25

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF57997	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
33705380	Molecular characterization of the conoid complex in Toxoplasma reveals itsconservation in all apicomplexans, including Plasmodium species.	Koreny L, Zeeshan M, ..., Waller RF	10.1371/journal.pbio.3001081