About Gene List

PF3D7_0322400

Genome location: Pf3D7_03_v3:942,090..945,625(+)

Genome classification: Core

Function and Localization

Product Description: regulator of initiation factor 2 (eIF2)

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.40 0.81
Trophozoite expressed 0.57 0.68
Schizont expressed 0.15 0.91
Gametocyte expressed 0.61 0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0322400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.146 | MFS: -2.823 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H485

"Best" AlphaFill ligand hit: UMP (2'-deoxyuridine 5'-monophosphate, Local RMSD=0.65) with 7S01 (Global RMSD=25.13)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532350

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 38 21 52
disruptive 27 118 73 155
missense 23 101 68 135

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 15 76 36 52
disruptive 51 286 122 270
missense 39 239 98 162

PlasmoDB Total SNPs: 168

Non-coding: 41 | Synonymous: 71 | Nonsynonymous: 55 | Stop Codon: 1

Protein Information

Protein Length: 867 | Molecular Weight (kDa): 104.776

UniProt ID(s): C0H485

PDB ID(s): None

Isoelectric Point: 6.25

Protein Domain Annotations:

Source Family ID Description
InterPro IPR009772 Cell division cycle protein 123
PFam PF07065 Cell division cycle protein 123
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095