Product Description: iron-sulfur assembly protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0051537 | 2 iron, 2 sulfur cluster binding |
| Process | GO:0016226 | iron-sulfur cluster assembly |
| Process | GO:0097428 | protein maturation by iron-sulfur cluster transfer |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.07 | 0.97 |
| Trophozoite | expressed | 0.47 | 0.72 |
| Schizont | expressed | 0.46 | 0.70 |
| Gametocyte | possibly expressed | 0.60 | 0.66 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0322500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.987 | MFS: -2.083 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1237400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97297
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101081
Most Similar Human Ortholog: A0A1B0GTK6
TM-align score: 0.86 | RMSD: 1.59
Seq Identity: 0.25 | Length: 91 / 404
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000135070 | iron-sulfur cluster assembly 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 15 | 10 | 14 |
| disruptive | 14 | 43 | 25 | 53 |
| missense | 6 | 38 | 21 | 44 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 29 | 11 | 21 |
| disruptive | 34 | 97 | 42 | 96 |
| missense | 16 | 76 | 33 | 64 |
PlasmoDB Total SNPs: 121
Non-coding: 37 | Synonymous: 25 | Nonsynonymous: 59 | Stop Codon: 0
Protein Length: 404 | Molecular Weight (kDa): 49.217
PDB ID(s): None
Isoelectric Point: 9.53
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR016092 | FeS cluster insertion protein |
| InterPro | IPR017870 | FeS cluster insertion, C-terminal, conserved site |
| InterPro | IPR035903 | HesB-like domain superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF89360 | HesB-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 34032321 | [Fe-S] biogenesis and unusual assembly of the ISC scaffold complex in thePlasmodium falciparum mitochondrion. | Mohammad Sadik, Mohammad Afsar, Ramachandran R, Habib S | 10.1111/mmi.14735 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |