PF3D7_0322600

Genome location: Pf3D7_03_v3:948,374..952,693(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Process	GO:0006897	endocytosis
Process	GO:0016197	endosomal transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.04	0.97
Schizont	not expressed	0.04	0.97
Gametocyte	not expressed	0.52	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0322600

Resistome Missense Mutations: D106E

Resistome Compounds with Missense Mutations: MMV665882

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.863 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1215900)

Relative Growth Rate: 1.02 ± 0.17
Confidence: 4.90

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1215900)

Modification: Disrupted | RMgm-3250

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97322

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533090

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	86	31	83
disruptive	62	198	94	241
missense	40	181	83	209

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	27	138	60	109
disruptive	103	399	180	372
missense	66	328	150	270

PlasmoDB Total SNPs: 180

Non-coding: 63 | Synonymous: 47 | Nonsynonymous: 70 | Stop Codon: 0

Protein Information

Protein Length: 1347 | Molecular Weight (kDa): 162.249

UniProt ID(s): O97322

PDB ID(s): None

Isoelectric Point: 7.51

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
PFam	N/A	N/A
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095