PF3D7_0322700

Genome location: Pf3D7_03_v3:952,746..963,144(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 7

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.86	0.62
Trophozoite	expressed	1.07	0.47
Schizont	possibly expressed	0.52	0.72
Gametocyte	not expressed	1.04	0.49

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0322700

Resistome Missense Mutations: S3000F

Resistome Compounds with Missense Mutations: BI-2536

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 2 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.14 | MFS: -2.941 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_111912

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	43	149	70	148
disruptive	163	475	210	548
missense	93	386	187	467

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	74	257	111	177
disruptive	300	936	359	823
missense	159	742	278	540

PlasmoDB Total SNPs: 624

Non-coding: 68 | Synonymous: 326 | Nonsynonymous: 230 | Stop Codon: 0

Protein Information

Protein Length: 3096 | Molecular Weight (kDa): 372.686

UniProt ID(s): O97298

PDB ID(s): None

Isoelectric Point: 9.3

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095