Product Description: 40S ribosomal protein S3A, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 1.47 | 0.41 |
| Trophozoite | expressed | 1.75 | 0.27 |
| Schizont | expressed | 0.38 | 0.77 |
| Gametocyte | not expressed | 0.83 | 0.57 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0322900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.13 | MFS: -2.796 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97313
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100723
Most Similar Human Ortholog: D6RB09
TM-align score: 0.99 | RMSD: 0.53
Seq Identity: 0.56 | Length: 193 / 262
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000145425 | ribosomal protein S3A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 14 | 4 | 20 |
| disruptive | 0 | 2 | 0 | 10 |
| missense | 0 | 2 | 0 | 6 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 35 | 10 | 14 |
| disruptive | 3 | 19 | 7 | 50 |
| missense | 0 | 6 | 5 | 28 |
PlasmoDB Total SNPs: 117
Non-coding: 107 | Synonymous: 9 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 262 | Molecular Weight (kDa): 30.047
UniProt ID(s): O97313
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP, 6OKK
Isoelectric Point: 10.47
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001593 | Ribosomal protein S3Ae |
| InterPro | IPR027500 | 40S ribosomal protein S1/3, eukaryotes |
| PFam | PF01015 | Ribosomal protein S3Ae |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |