About Gene List

PF3D7_0323100

Genome location: Pf3D7_03_v3:969,875..976,203(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005789 endoplasmic reticulum membrane
Function GO:0005096 GTPase activator activity
Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.26 0.87
Trophozoite expressed 0.85 0.55
Schizont possibly expressed 0.62 0.65
Gametocyte possibly expressed 0.93 0.53

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0323100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.131 | MFS: -2.925 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1215400)

  • Relative Growth Rate: 0.12 ± 0.30
  • Confidence: 3.81

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97299

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103152

Most Similar Human Ortholog: A0A7P0TBA8

TM-align score: 0.80 | RMSD: 2.33

Seq Identity: 0.21 | Length: 181 / 1542

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000125875 TBC1 domain family member 20

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 14 74 48 68
disruptive 48 185 84 239
missense 45 165 76 207

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 34 137 54 93
disruptive 100 398 174 415
missense 79 322 144 252

PlasmoDB Total SNPs: 235

Non-coding: 113 | Synonymous: 85 | Nonsynonymous: 37 | Stop Codon: 0

Protein Information

Protein Length: 1542 | Molecular Weight (kDa): 184.461

UniProt ID(s): O97299

PDB ID(s): None

Isoelectric Point: 10.05

Protein Domain Annotations:

Source Family ID Description
InterPro IPR035969 Rab-GTPase-TBC domain superfamily
PFam N/A N/A
Superfamily SSF47923 Rab-GTPase-TBC domain superfamily

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095