PF3D7_0323300

Genome location: Pf3D7_03_v3:978,970..980,271(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.05	0.97
Schizont	possibly expressed	0.05	0.97
Gametocyte	expressed	0.20	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0323300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.131 | MFS: -3.005 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97301

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_106611

Most Similar Human Ortholog: Q8N8R5

TM-align score: 0.58 | RMSD: 3.58

Seq Identity: 0.23 | Length: 258 / 433

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000178074	chromosome 2 open reading frame 69

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	8	7	19
disruptive	10	36	15	55
missense	6	31	15	50

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	19	15	25
disruptive	22	69	38	93
missense	13	57	33	78

PlasmoDB Total SNPs: 35

Non-coding: 0 | Synonymous: 24 | Nonsynonymous: 9 | Stop Codon: 2

Protein Information

Protein Length: 433 | Molecular Weight (kDa): 51.529

UniProt ID(s): O97301

PDB ID(s): None

Isoelectric Point: 6.19

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR018881	Uncharacterised protein family UPF0565
PFam	PF10561	Uncharacterised protein family UPF0565
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095