Product Description: survival motor neuron-like protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.1.31.1 (Micrococcal nuclease)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Component | GO:0005681 | spliceosomal complex |
| Function | GO:0003723 | RNA binding |
| Function | GO:0004518 | nuclease activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.58 | 0.72 |
| Trophozoite | expressed | 0.59 | 0.66 |
| Schizont | expressed | 0.25 | 0.85 |
| Gametocyte | possibly expressed | 0.31 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0323500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.122 | MFS: -2.931 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97304
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.1.31.1 | micrococcal nuclease | SDSEDTAcaspase-3Mononucleotidesoligonucleotidesmetacaspase mcII-Paadenosine 3',5'-diphosphatethymidine 3',5'-bisphosphate3',5'-deoxythymidine diphosphatedeoxythymidine 3',5'-diphosphatedeoxythymidine 3',5'-bisphosphate2'-deoxythymidine 3',5'-diphosphate |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103070
Most Similar Human Ortholog: A0A6Q8PG47
TM-align score: 0.39 | RMSD: 1.70
Seq Identity: 0.21 | Length: 48 / 315
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000119953 | survival motor neuron domain containing 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 4 | 2 | 16 |
| disruptive | 5 | 14 | 9 | 24 |
| missense | 4 | 14 | 9 | 20 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 11 | 10 | 14 |
| disruptive | 7 | 33 | 36 | 63 |
| missense | 5 | 27 | 31 | 46 |
PlasmoDB Total SNPs: 111
Non-coding: 99 | Synonymous: 9 | Nonsynonymous: 2 | Stop Codon: 1
Protein Length: 315 | Molecular Weight (kDa): 37.461
UniProt ID(s): O97304
PDB ID(s): None
Isoelectric Point: 7.43
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002999 | Tudor domain |
| PFam | N/A | N/A |
| Superfamily | SSF63748 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 18035357 | Tudor domain proteins in protozoan parasites and characterization of Plasmodiumfalciparum tudor staphylococcal nuclease. | Hossain MJ, Korde R, ..., Malhotra P | 10.1016/j.ijpara.2007.09.018 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |