About Gene List

PF3D7_0323600

Genome location: Pf3D7_03_v3:988,165..991,120(+)

Genome classification: Core

Function and Localization

Product Description: BSD domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.21 0.89
Trophozoite not expressed 0.54 0.68
Schizont possibly expressed 0.12 0.92
Gametocyte not expressed 0.32 0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0323600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.2 | MFS: -3.309 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97305

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533622

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 18 9 16
disruptive 8 37 29 54
missense 8 35 28 50

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 11 31 12 28
disruptive 14 93 55 139
missense 9 79 44 92

PlasmoDB Total SNPs: 77

Non-coding: 38 | Synonymous: 26 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 670 | Molecular Weight (kDa): 80.694

UniProt ID(s): O97305

PDB ID(s): None

Isoelectric Point: 5.45

Protein Domain Annotations:

Source Family ID Description
InterPro IPR005607 BSD domain
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
26292257 Discovery of Novel Plasmodium falciparum Pre-Erythrocytic Antigens for VaccineDevelopment. Aguiar JC, Bolton J, ..., Richie TL 10.1371/journal.pone.0136109