About Gene List

PF3D7_0323700 (SART1)

Genome location: Pf3D7_03_v3:991,037..994,381(-)

Genome classification: Core

Function and Localization

Product Description: U4/U6.U5 tri-snRNP-associated protein 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0046540 U4/U6 x U5 tri-snRNP complex
Component GO:0005634 nucleus
Process GO:0045292 mRNA cis splicing, via spliceosome
Process GO:0000481 maturation of 5S rRNA

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.92 0.59
Trophozoite expressed 0.85 0.55
Schizont expressed 0.62 0.65
Gametocyte possibly expressed 0.56 0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0323700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.432 | MFS: -2.425 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97303

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=6.20) with 4FI1 (Global RMSD=18.54)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_145554

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 10 20 14 20
disruptive 36 85 37 102
missense 19 66 26 81

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 13 40 17 29
disruptive 65 184 82 178
missense 32 126 59 126

PlasmoDB Total SNPs: 167

Non-coding: 63 | Synonymous: 58 | Nonsynonymous: 46 | Stop Codon: 0

Protein Information

Protein Length: 693 | Molecular Weight (kDa): 82.9

UniProt ID(s): O97303, Q9BJX1, Q9GTW4

PDB ID(s): None

Isoelectric Point: 5.09

Protein Domain Annotations:

Source Family ID Description
InterPro IPR005011 SNU66/SART1 family
PFam PF03343 SNU66/SART1 family
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
21614000 Role of the ubiquitin-like protein Hub1 in splice-site usage and alternativesplicing. Mishra SK, Ammon T, ..., Jentsch S 10.1038/nature10143