About Gene List

PF3D7_0323800

Genome location: Pf3D7_03_v3:995,923..1,001,997(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus
Function GO:0003729 mRNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.27 0.86
Trophozoite possibly expressed 0.45 0.73
Schizont possibly expressed 0.22 0.86
Gametocyte expressed 0.55 0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0323800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.909 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1214700)

Modification: Disrupted | RMgm-3248

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97306

"Best" AlphaFill ligand hit: 1CY (1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine, Local RMSD=5.44) with 3UM6 (Global RMSD=23.18)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533305

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 10 36 15 37
disruptive 31 107 40 112
missense 17 79 30 79

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 14 65 34 48
disruptive 75 219 122 353
missense 39 156 89 171

PlasmoDB Total SNPs: 221

Non-coding: 151 | Synonymous: 45 | Nonsynonymous: 25 | Stop Codon: 0

Protein Information

Protein Length: 977 | Molecular Weight (kDa): 114.842

UniProt ID(s): O97306

PDB ID(s): None

Isoelectric Point: 8.77

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
27381095 The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. Bunnik EM, Batugedara G, ..., Le Roch KG 10.1186/s13059-016-1014-0