About Gene List

PF3D7_0324000 (EPF1)

Genome location: Pf3D7_03_v3:1,005,952..1,006,800(+)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: exported protein family 1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data nd 1.00
Trophozoite no data nd 1.00
Schizont no data nd 1.00
Gametocyte no data nd 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0324000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.579 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_126097

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 68

Non-coding: 0 | Synonymous: 67 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 282 | Molecular Weight (kDa): 33.398

UniProt ID(s): O97462

PDB ID(s): None

Isoelectric Point: 4.58

Protein Domain Annotations:

Source Family ID Description
InterPro IPR026894 DNAJ-containing protein, X-domain
PFam PF14308 DNAJ-containing protein, X-domain
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
9804551 Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Tettelin H, ..., Hoffman SL 10.1126/science.282.5391.1126
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23517413 Novel Plasmodium falciparum Maurer's clefts protein families implicated in therelease of infectious merozoites. Mbengue A, Audiger N, ..., Braun-Breton C 10.1111/mmi.12193
31937828 Investigating a Plasmodium falciparum erythrocyte invasion phenotype switch atthe whole transcriptome level Nyarko PB, Tarr SJ, ..., Awandare GA 10.1038/s41598-019-56386-y