About Gene List

PF3D7_0324100 (MC-2TM)

Genome location: Pf3D7_03_v3:1,007,145..1,008,491(-)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: Pfmc-2TM Maurer's cleft two transmembrane protein

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0016021 integral component of membrane
Component GO:0016020 membrane
Process GO:0042000 translocation of peptides or proteins into host

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.01 1.00
Trophozoite expressed 0.07 0.98
Schizont not expressed 0.01 1.00
Gametocyte not expressed 0.01 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0324100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.453 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97307

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_122335

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 234

Non-coding: 47 | Synonymous: 36 | Nonsynonymous: 145 | Stop Codon: 6

Protein Information

Protein Length: 231 | Molecular Weight (kDa): 27.005

UniProt ID(s): O97307

PDB ID(s): None

Isoelectric Point: 9.94

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
15140830 A Plasmodium gene family encoding Maurer's cleft membrane proteins: structuralproperties and expression profiling. Sam-Yellowe TY, Florens L, ..., Yates JR 3rd 10.1101/gr.2126104
33916455 Trafficking and Association of Plasmodium falciparum MC-2TM with the Maurer'sClefts Yadavalli R, Peterson JW, Drazba JA, Sam-Yellowe TY 10.3390/pathogens10040431