Genome location: Pf3D7_03_v3:1,018,874..1,019,973(+)
Genome classification: SubtelomericHypervariable
Product Description: rifin
SignalP Peptide: MKLHYTKILLFFFPLYILVTS
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | nd | 1.00 |
| Trophozoite | not expressed | 0.00 | 1.00 |
| Schizont | not expressed | 0.00 | 1.00 |
| Gametocyte | not expressed | 0.00 | 1.00 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0324500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.898 | MFS: -2.014 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97310
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 458
Non-coding: 41 | Synonymous: 93 | Nonsynonymous: 312 | Stop Codon: 12
Protein Length: 317 | Molecular Weight (kDa): 35.812
UniProt ID(s): O97310, Q2XRA4, Q2XRB9, Q2XRD4, Q2XRF6, Q2XRH4
PDB ID(s): None
Isoelectric Point: 9.83
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006373 | Variant surface antigen Rifin |
| PFam | PF02009 | Variant surface antigen Rifin |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |