About Gene List

PF3D7_0324600

Genome location: Pf3D7_03_v3:1,021,998..1,023,008(+)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: stevor

SignalP Peptide: MKMYNLKMLLFTFLINTLA

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0033644 host cell membrane
Component GO:0005886 plasma membrane
Process GO:0020013 modulation by symbiont of host erythrocyte aggregation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.00 1.00
Trophozoite expressed 0.00 1.00
Schizont possibly expressed nd 1.00
Gametocyte possibly expressed 0.00 1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0324600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.967 | MFS: -2.076 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9U5M0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109391

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 485

Non-coding: 47 | Synonymous: 188 | Nonsynonymous: 247 | Stop Codon: 3

Protein Information

Protein Length: 301 | Molecular Weight (kDa): 33.758

UniProt ID(s): O96488, Q9BMD1, Q9U5M0

PDB ID(s): None

Isoelectric Point: 8.9

Protein Domain Annotations:

Source Family ID Description
InterPro IPR006374 Variant surface antigen Stevor
InterPro IPR036259 MFS transporter superfamily
PFam PF17410 Variant surface antigen Stevor
Superfamily SSF103473 MFS transporter superfamily

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
25011110 STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediatesmerozoite invasion and rosetting. Niang M, Bei AK, ..., Preiser PR 10.1016/j.chom.2014.06.004
31363031 Dissecting the Gene Expression, Localization, Membrane Topology, and Function ofthe Plasmodium falciparum S TEVOR Protein Family Wichers JS, Scholz JAM, ..., Bachmann A 10.1128/mBio.01500-19