Genome location: Pf3D7_03_v3:1,030,822..1,038,254(-)
Genome classification: SubtelomericHypervariable
Product Description: erythrocyte membrane protein 1, PfEMP1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | expressed | 0.04 | 0.98 |
Trophozoite | expressed | 0.07 | 0.95 |
Schizont | expressed | 0.15 | 0.89 |
Gametocyte | expressed | 0.14 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0324900
Resistome Missense Mutations: A978P, N2139T, N2139D
Resistome Compounds with Missense Mutations: AN13762, MMV024101
Resistome # Samples with Disruptive Mutations: 4 (4 missense, 0 "interesting" missense)
Zhang Phenotype: N/A
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97312
"Best" AlphaFill ligand hit: 3PO (triphosphate, Local RMSD=1.50) with 5MZA (Global RMSD=8.77)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 2524
Non-coding: 418 | Synonymous: 662 | Nonsynonymous: 1432 | Stop Codon: 12
Protein Length: 2169 | Molecular Weight (kDa): 246.915
UniProt ID(s): A0A0F6P8T9, A0A0F6P8U4, A0A0F6P8X8, A0A5P1A0A9, A0A5P1A0Q2, A0A5P1A144, A0A5P1A149, A0A5P1A1C5, A0A5P1A1V5, A0A5P1A295, O97312
PDB ID(s): None
Isoelectric Point: 5.05
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR004258 | Duffy-binding-like domain |
InterPro | IPR008602 | Duffy-antigen binding |
InterPro | IPR029210 | Plasmodium falciparum erythrocyte membrane protein-1, N-terminal segment |
InterPro | IPR029211 | Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment |
InterPro | IPR041480 | Cysteine-rich interdomain region 1 gamma |
PFam | PF03011 | Duffy-binding-like domain |
PFam | PF05424 | Duffy-antigen binding |
PFam | PF15445 | Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment |
PFam | PF15447 | Plasmodium falciparum erythrocyte membrane protein-1, N-terminal segment |
PFam | PF18562 | Cysteine-rich interdomain region 1 gamma |
Superfamily | SSF140924 | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |