About Gene List

PF3D7_0324900 (VAR)

Genome location: Pf3D7_03_v3:1,030,822..1,038,254(-)

Genome classification: SubtelomericHypervariable

Function and Localization

Product Description: erythrocyte membrane protein 1, PfEMP1

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.04 0.98
Trophozoite expressed 0.07 0.95
Schizont expressed 0.15 0.89
Gametocyte expressed 0.14 0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0324900

Resistome Missense Mutations: A978P, N2139T, N2139D

Resistome Compounds with Missense Mutations: AN13762, MMV024101

Resistome # Samples with Disruptive Mutations: 4 (4 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: N/A

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97312

"Best" AlphaFill ligand hit: 3PO (triphosphate, Local RMSD=1.50) with 5MZA (Global RMSD=8.77)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104345

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 2524

Non-coding: 418 | Synonymous: 662 | Nonsynonymous: 1432 | Stop Codon: 12

Protein Information

Protein Length: 2169 | Molecular Weight (kDa): 246.915

UniProt ID(s): A0A0F6P8T9, A0A0F6P8U4, A0A0F6P8X8, A0A5P1A0A9, A0A5P1A0Q2, A0A5P1A144, A0A5P1A149, A0A5P1A1C5, A0A5P1A1V5, A0A5P1A295, O97312

PDB ID(s): None

Isoelectric Point: 5.05

Protein Domain Annotations:

Source Family ID Description
InterPro IPR004258 Duffy-binding-like domain
InterPro IPR008602 Duffy-antigen binding
InterPro IPR029210 Plasmodium falciparum erythrocyte membrane protein-1, N-terminal segment
InterPro IPR029211 Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment
InterPro IPR041480 Cysteine-rich interdomain region 1 gamma
PFam PF03011 Duffy-binding-like domain
PFam PF05424 Duffy-antigen binding
PFam PF15445 Plasmodium falciparum erythrocyte membrane protein 1, acidic terminal segment
PFam PF15447 Plasmodium falciparum erythrocyte membrane protein-1, N-terminal segment
PFam PF18562 Cysteine-rich interdomain region 1 gamma
Superfamily SSF140924 N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095