Genome location: Pf3D7_04_v3:92,418..94,121(-)
Genome classification: SubtelomericHypervariable
Product Description: rifin
SignalP Peptide: MLLCLFLLNKLLLLLLLLPLLLS
# Transmembrane Domains: 3
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | nd | nd |
| Trophozoite | expressed | nd | nd |
| Schizont | expressed | nd | nd |
| Gametocyte | not expressed | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0401600.2
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.962 | MFS: -2.624 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZXC7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 6 | 2 | 9 |
| disruptive | 66 | 27 | 10 | 32 |
| missense | 32 | 17 | 4 | 21 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 7 | 10 | 13 |
| disruptive | 76 | 59 | 27 | 64 |
| missense | 34 | 31 | 21 | 41 |
PlasmoDB Total SNPs: 183
Non-coding: 53 | Synonymous: 23 | Nonsynonymous: 104 | Stop Codon: 3
Protein Length: 347 | Molecular Weight (kDa): 40.144
UniProt ID(s): Q8I209
PDB ID(s): None
Isoelectric Point: 9.98
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006373 | Variant surface antigen Rifin |
| PFam | PF02009 | Variant surface antigen Rifin |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 32732983 | In vitro selection for adhesion of Plasmodium falciparum-infected erythrocytes toABO antigens does not affect PfEMP1 and RIFIN expression. | van der Puije W, Wang CW, ..., Staalsoe T | 10.1038/s41598-020-69666-9 |
| 33647792 | Plasmodium falciparum RIFIN is a novel ligand for inhibitory immune receptorLILRB2. | Sakoguchi A, Saito F, ..., Arase H | 10.1016/j.bbrc.2021.02.033 |