About Gene List

PF3D7_0402100

Genome location: Pf3D7_04_v3:123,068..125,848(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein (PHISTb), unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020036 Maurer's cleft
Component GO:0043657 host cell
Function GO:0005515 protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 2.21 0.24
Trophozoite possibly expressed 0.59 0.70
Schizont expressed 0.45 0.75
Gametocyte not expressed 0.31 0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0402100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.876 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I205

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_131849

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 26 9 27
disruptive 24 69 34 100
missense 19 63 30 92

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 43 17 36
disruptive 36 136 48 141
missense 28 116 45 110

PlasmoDB Total SNPs: 164

Non-coding: 114 | Synonymous: 19 | Nonsynonymous: 31 | Stop Codon: 0

Protein Information

Protein Length: 575 | Molecular Weight (kDa): 67.788

UniProt ID(s): Q8I205

PDB ID(s): None

Isoelectric Point: 4.22

Protein Domain Annotations:

Source Family ID Description
InterPro IPR019111 Plasmodium RESA, N-terminal
PFam PF09687 Plasmodium RESA, N-terminal
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
28288121 A genetic system to study Plasmodium falciparum protein function. Birnbaum J, Flemming S, ..., Spielmann T 10.1038/nmeth.4223
31125575 The Plasmodium falciparum MESA erythrocyte cytoskeleton-binding (MEC) motif bindsto erythrocyte ankyrin. Kilili GK, Shakya B, ..., LaCount DJ 10.1016/j.molbiopara.2019.111189
31631203 A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. Das D, Krishnan SR, Roy A, Bulusu G 10.1039/c9mo00124g