PF3D7_0402300 (RH1)

Genome location: Pf3D7_04_v3:137,006..147,177(+)

Genome classification: Core

Function and Localization

Product Description: reticulocyte binding protein homologue 1

SignalP Peptide: MQRWIFCNIVLHILIYLAEF

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020007	apical complex
Component	GO:0020008	rhoptry
Function	GO:0008201	heparin binding
Function	GO:0046789	host cell surface receptor binding
Process	GO:0098609	cell-cell adhesion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	1.16	0.68
Trophozoite	not expressed	0.22	0.89
Schizont	expressed	0.59	0.79
Gametocyte	not expressed	0.15	0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0402300

Resistome Missense Mutations: K1244N

Resistome Compounds with Missense Mutations: GNF-Pf-3600

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.533 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532540

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	30	124	71	177
disruptive	171	427	229	529
missense	138	378	212	462

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	48	249	113	205
disruptive	264	795	392	781
missense	197	666	351	568

PlasmoDB Total SNPs: 424

Non-coding: 93 | Synonymous: 158 | Nonsynonymous: 173 | Stop Codon: 0

Protein Information

Protein Length: 2971 | Molecular Weight (kDa): 357.669

UniProt ID(s): A0A159SJD5, A0A159SJF1, A0A159SJH6, A0A159SK28, A0A159SKT8, A0A159SL63, A0A161FAQ2, A0A2S1Q7M9, A0A2S1Q7N0, A0A2S1Q7N6, A0A2S1Q7P3, B9ZSJ4, Q25908, Q7KF73, Q7YUE9, Q8WP99, Q8WRS4, Q8WRS5, Q8WRS6

PDB ID(s): None

Isoelectric Point: 8.24

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
11733572	A Plasmodium falciparum homologue of Plasmodium vivax reticulocyte bindingprotein (PvRBP1) defines a trypsin-resistant erythrocyte invasion pathway.	Rayner JC, Vargas-Serrato E, ..., Barnwell JW	10.1084/jem.194.11.1571
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
24212193	Analyses of interactions between heparin and the apical surface proteins ofPlasmodium falciparum.	Kobayashi K, Takano R, ..., Kato K	10.1038/srep03178