About Gene List

PF3D7_0402400 (GEXP18)

Genome location: Pf3D7_04_v3:146,710..149,188(-)

Genome classification: Core

Function and Localization

Product Description: Plasmodium exported protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0043657 host cell
Component GO:0032991 protein-containing complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.88 0.59
Trophozoite expressed 0.85 0.55
Schizont expressed 0.79 0.54
Gametocyte expressed 0.24 0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0402400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.813 | MFS: -2.989 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I202

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=3.70) with 6JWQ (Global RMSD=7.46)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533126

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 1 0
disruptive 0 0 0 0
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 1 0 0
disruptive 0 0 0 0
missense 0 0 0 0

PlasmoDB Total SNPs: 192

Non-coding: 169 | Synonymous: 8 | Nonsynonymous: 14 | Stop Codon: 1

Protein Information

Protein Length: 254 | Molecular Weight (kDa): 31.019

UniProt ID(s): Q8I202

PDB ID(s): None

Isoelectric Point: 7.77

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16507167 Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. Sargeant TJ, Marti M, ..., Cowman AF 10.1186/gb-2006-7-2-r12
35198913 Serological evaluation of the effectiveness of reactive focal mass drugadministration and reactive vector control to reduce malaria transmission inZambezi Region, Namibia: Results from a secondary analysis of a clusterrandomised trial Wu L, Hsiang MS, ..., Kleinschmidt I 10.1016/j.eclinm.2022.101272
33183292 Sero-epidemiological evaluation of malaria transmission in The Gambia before andafter mass drug administration Wu L, Mwesigwa J, ..., Drakeley C 10.1186/s12916-020-01785-6
32972398 Antibody responses to a suite of novel serological markers for malariasurveillance demonstrate strong correlation with clinical and parasitologicalinfection across seasons and transmission settings in The Gambia Wu L, Mwesigwa J, ..., Drakeley C 10.1186/s12916-020-01724-5
37693871 Analytical approaches for antimalarial antibody responses to confirm historicaland recent malaria transmission: an example from the Philippines Macalinao MLM, Fornace KM, ..., Drakeley CJ 10.1016/j.lanwpc.2023.100792