PF3D7_0402900

Genome location: Pf3D7_04_v3:172,256..173,440(-)

Genome classification: Core

Function and Localization

Product Description: probable protein, unknown function

SignalP Peptide: MKILFFFFVILSFFNIIEIIGS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.05	0.97
Trophozoite	no data	0.01	1.00
Schizont	no data	0.01	1.00
Gametocyte	no data	0.00	1.00

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0402900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.202 | MFS: 0.236 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I200

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533733

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	0
disruptive	0	0	1	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	rare	doubleton	singleton
synonymous	0	0	0
disruptive	1	1	3
missense	0	0	0

PlasmoDB Total SNPs: 93

Non-coding: 82 | Synonymous: 4 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 99 | Molecular Weight (kDa): 11.613

UniProt ID(s): Q8I200

PDB ID(s): None

Isoelectric Point: 4.3

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A