About Gene List

PF3D7_0403100

Genome location: Pf3D7_04_v3:175,003..177,360(-)

Genome classification: Core

Function and Localization

Product Description: regulator of chromosome condensation, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed 0.10 0.95
Trophozoite expressed 0.25 0.85
Schizont expressed 0.09 0.94
Gametocyte expressed 0.19 0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0403100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.141 | MFS: -2.908 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1Z9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139503

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 29 27 44
disruptive 10 70 48 92
missense 10 70 47 87

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 72 29 43
disruptive 25 158 77 132
missense 21 140 66 100

PlasmoDB Total SNPs: 80

Non-coding: 39 | Synonymous: 26 | Nonsynonymous: 15 | Stop Codon: 0

Protein Information

Protein Length: 626 | Molecular Weight (kDa): 73.136

UniProt ID(s): Q8I1Z9

PDB ID(s): None

Isoelectric Point: 8.8

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000408 Regulator of chromosome condensation, RCC1
InterPro IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
PFam PF13540 N/A
Superfamily SSF50985 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21