PF3D7_0403200

Genome location: Pf3D7_04_v3:177,783..181,051(+)

Genome classification: Core

Function and Localization

Product Description: pre-mRNA splicing factor, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.67	0.69
Trophozoite	expressed	0.73	0.60
Schizont	possibly expressed	0.19	0.88
Gametocyte	possibly expressed	0.56	0.69

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0403200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.513 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1000800)

Modification: Disrupted | RMgm-2698

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1Z8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_121023

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	26	10	39
disruptive	39	109	51	132
missense	15	83	37	82

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	56	22	36
disruptive	78	224	92	223
missense	30	150	70	121

PlasmoDB Total SNPs: 186

Non-coding: 69 | Synonymous: 79 | Nonsynonymous: 37 | Stop Codon: 1

Protein Information

Protein Length: 560 | Molecular Weight (kDa): 69.423

UniProt ID(s): Q8I1Z8

PDB ID(s): None

Isoelectric Point: 10.23

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR022209	Pre-mRNA splicing factor
PFam	PF12542	Pre-mRNA splicing factor
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104