PF3D7_0403400

Genome location: Pf3D7_04_v3:181,969..194,734(+)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.38	0.45
Trophozoite	expressed	1.17	0.43
Schizont	expressed	0.59	0.68
Gametocyte	expressed	1.00	0.50

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0403400

Resistome Missense Mutations: T609N

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 8 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.936 | MFS: -2.787 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160307

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	52	229	110	250
disruptive	269	672	383	803
missense	148	512	325	640

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	93	431	178	256
disruptive	451	1441	554	1178
missense	237	1083	426	765

PlasmoDB Total SNPs: 681

Non-coding: 88 | Synonymous: 299 | Nonsynonymous: 293 | Stop Codon: 1

Protein Information

Protein Length: 3825 | Molecular Weight (kDa): 460.086

UniProt ID(s): C0H487

PDB ID(s): None

Isoelectric Point: 9.75

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007309	B-block binding subunit of TFIIIC
InterPro	IPR013087	Zinc finger C2H2-type
PFam	PF04182	B-block binding subunit of TFIIIC
Superfamily	N/A	N/A