PF3D7_0403600

Genome location: Pf3D7_04_v3:197,685..202,175(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.98
Trophozoite	expressed	0.43	0.74
Schizont	expressed	0.40	0.76
Gametocyte	expressed	0.46	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0403600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.944 | MFS: -1.816 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1001300)

Modification: Disrupted | RMgm-4243

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H488

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532808

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	14	45	25	56
disruptive	49	100	56	132
missense	30	72	49	110

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	21	84	44	57
disruptive	71	220	111	238
missense	40	161	91	167

PlasmoDB Total SNPs: 395

Non-coding: 303 | Synonymous: 33 | Nonsynonymous: 57 | Stop Codon: 2

Protein Information

Protein Length: 768 | Molecular Weight (kDa): 89.432

UniProt ID(s): C0H488

PDB ID(s): None

Isoelectric Point: 5.4

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A