Product Description: pre-mRNA-splicing factor CLF1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000974 | Prp19 complex |
| Component | GO:0071007 | U2-type catalytic step 2 spliceosome |
| Component | GO:0071004 | U2-type prespliceosome |
| Component | GO:0071013 | catalytic step 2 spliceosome |
| Component | GO:0071014 | post-mRNA release spliceosomal complex |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003682 | chromatin binding |
| Process | GO:0006270 | DNA replication initiation |
| Process | GO:0000354 | cis assembly of pre-catalytic spliceosome |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
| Process | GO:0000245 | spliceosomal complex assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.66 | 0.68 |
| Trophozoite | expressed | 0.81 | 0.56 |
| Schizont | expressed | 0.29 | 0.82 |
| Gametocyte | expressed | 0.74 | 0.60 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0403700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.979 | MFS: -2.886 | #Insertions: 1
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1001400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I1Z2
"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=4.20) with 3EFS (Global RMSD=18.36)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101977
Most Similar Human Ortholog: Q9BZJ0
TM-align score: 0.66 | RMSD: 5.03
Seq Identity: 0.33 | Length: 630 / 780
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000101343 | crooked neck pre-mRNA splicing factor 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 40 | 28 | 62 |
| disruptive | 25 | 61 | 43 | 98 |
| missense | 16 | 49 | 39 | 73 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 94 | 44 | 55 |
| disruptive | 40 | 149 | 106 | 229 |
| missense | 21 | 112 | 83 | 148 |
PlasmoDB Total SNPs: 382
Non-coding: 230 | Synonymous: 60 | Nonsynonymous: 91 | Stop Codon: 1
Protein Length: 780 | Molecular Weight (kDa): 94.018
UniProt ID(s): Q8I1Z2
PDB ID(s): None
Isoelectric Point: 4.59
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003107 | HAT (Half-A-TPR) repeat |
| InterPro | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF48452 | Tetratricopeptide-like helical domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 34436980 | Antiproliferative activity on Trypanosoma cruzi (Y strain) of the triterpene3beta,6beta,16beta-trihidroxilup-20 (29)-ene isolated from Combretum leprosum | de Araujo JIF, Aires NL, ..., Dos Santos HS | 10.1080/07391102.2021.1970025 |