PF3D7_0403800

Genome location: Pf3D7_04_v3:209,977..216,599(-)

Genome classification: Core

Function and Localization

Product Description: alpha/beta hydrolase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.63	0.78
Trophozoite	possibly expressed	0.25	0.85
Schizont	expressed	0.69	0.62
Gametocyte	expressed	0.57	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0403800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.128 | MFS: -2.948 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1225600)

Relative Growth Rate: 1.03 ± 0.08
Confidence: 6.45

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1001500)

Modification: Disrupted | RMgm-2703

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1Z1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100915

Most Similar Human Ortholog: H0YN98

TM-align score: 0.85 | RMSD: 1.63

Seq Identity: 0.22 | Length: 91 / 734

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000107362	abhydrolase domain containing 17B, depalmitoylase
ENSG00000129968	abhydrolase domain containing 17A, depalmitoylase
ENSG00000136379	abhydrolase domain containing 17C, depalmitoylase

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 426

Non-coding: 347 | Synonymous: 41 | Nonsynonymous: 38 | Stop Codon: 0

Protein Information

Protein Length: 734 | Molecular Weight (kDa): 83.377

UniProt ID(s): Q8I1Z1

PDB ID(s): None

Isoelectric Point: 9.86

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR022742	Serine aminopeptidase, S33
InterPro	IPR029058	Alpha/Beta hydrolase fold
PFam	PF12146	Serine aminopeptidase, S33
Superfamily	SSF53474	Alpha/Beta hydrolase fold