Product Description: conserved Plasmodium protein, unknown function
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | not expressed | 0.06 | 0.96 |
Trophozoite | not expressed | 0.01 | 1.00 |
Schizont | expressed | 0.41 | 0.77 |
Gametocyte | expressed | 0.26 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0404000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: -1.56 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1001700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I1Y9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 2 | 3 | 4 | 7 |
disruptive | 0 | 5 | 5 | 13 |
missense | 0 | 5 | 3 | 12 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 3 | 10 | 3 | 12 |
disruptive | 1 | 22 | 9 | 47 |
missense | 0 | 17 | 5 | 24 |
PlasmoDB Total SNPs: 115
Non-coding: 111 | Synonymous: 3 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 99 | Molecular Weight (kDa): 11.65
UniProt ID(s): Q8I1Y9
PDB ID(s): None
Isoelectric Point: 9.03
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | N/A | N/A |
PFam | N/A | N/A |
Superfamily | N/A | N/A |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |