PF3D7_0404200

Genome location: Pf3D7_04_v3:232,342..233,735(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.05	0.97
Schizont	not expressed	0.03	0.98
Gametocyte	not expressed	0.12	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0404200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.126 | MFS: -3.009 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1001900)

Relative Growth Rate: 0.11 ± 0.04
Confidence: 8.05

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1Y7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt	Protein Name	Species	Homology Source	BindingDB Ligands
P53051	Oligo-1,6-glucosidase IMA1		OrthoMCL	5-(hydroxymethyl)-2-(2-phenylethyl)-5H,6H,7H,8H- imidazo[1,2-a]pyridine-6,7,8-triol (Compound 2)2-(3,3-dimethylbutyl)-5-(hydroxymethyl)- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 3)5-(hydroxymethyl)-2-octyl-5H,6H,7H,8H-imidazo[1,2- a]pyridine-6,7,8-triol (Compound 4)5-(hydroxymethyl)-2-[3-(4-methylphenyl)propyl]- 5H,6H,7H,8H-imidazo[1,2-a]pyridine-6,7,8-triol (Compound 5)...
P53341	Alpha-glucosidase MAL12	Saccharomyces cerevisiae	OrthoMCL	Urea derivative, 11Urea derivative, 12Urea derivative, 13Urea derivative, 16...
P38158	Alpha-glucosidase MAL32		OrthoMCL	GSK-3965Riccardin CPPS-33Riccardin C derivative, 20b...

Orthology Information

Ortholog Group (OrthoMCL): OG6_100402

Most Similar Human Ortholog: Q07837

TM-align score: 0.32 | RMSD: 5.75

Seq Identity: 0.05 | Length: 104 / 163

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000138079	solute carrier family 3 member 1

Protein Information

Protein Length: 163 | Molecular Weight (kDa): 19.573

UniProt ID(s): Q8I1Y7

PDB ID(s): None

Isoelectric Point: 10.39

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	12	3	9
disruptive	2	15	8	26
missense	2	15	7	22

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	22	6	9
disruptive	7	39	25	52
missense	3	33	21	38

PlasmoDB Total SNPs: 61

Non-coding: 48 | Synonymous: 8 | Nonsynonymous: 5 | Stop Codon: 0