About Gene List

PF3D7_0404300

Genome location: Pf3D7_04_v3:233,990..237,708(-)

Genome classification: Core

Function and Localization

Product Description: Ran-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite no data N/A N/A
Ring no data 0.84 0.63
Trophozoite no data 1.35 0.37
Schizont no data 0.74 0.61
Gametocyte no data 1.06 0.46

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0404300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.999 | MFS: -1.699 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1Y6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533383

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 12 37 16 31
disruptive 61 128 71 105
missense 30 63 40 58

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 23 68 14 24
disruptive 91 222 78 155
missense 42 113 28 85

PlasmoDB Total SNPs: 418

Non-coding: 141 | Synonymous: 126 | Nonsynonymous: 151 | Stop Codon: 0

Protein Information

Protein Length: 631 | Molecular Weight (kDa): 74.183

UniProt ID(s): Q8I1Y6

PDB ID(s): None

Isoelectric Point: 3.7

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000156 Ran binding domain
PFam N/A N/A
Superfamily SSF50729 N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596