Product Description: 6-cysteine protein P36
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0046658 | anchored component of plasma membrane |
| Component | GO:0009986 | cell surface |
| Component | GO:0020009 | microneme |
| Function | GO:0005515 | protein binding |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.01 | 0.99 |
| Schizont | expressed | 0.02 | 0.98 |
| Gametocyte | expressed | 0.02 | 0.99 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0404400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.727 | #Insertions: 2
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1002200)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1002100)
Modification: Mutated | RMgm-4744
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I1Y5
"Best" AlphaFill ligand hit: ACP (adenosine-5'-[beta, gamma-methylene]triphosphate, Local RMSD=7.53) with 4OAV (Global RMSD=19.12)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 17 | 13 | 24 |
| disruptive | 8 | 26 | 13 | 34 |
| missense | 6 | 22 | 9 | 31 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 38 | 21 | 25 |
| disruptive | 17 | 56 | 22 | 74 |
| missense | 11 | 42 | 21 | 60 |
PlasmoDB Total SNPs: 25
Non-coding: 0 | Synonymous: 15 | Nonsynonymous: 9 | Stop Codon: 1
Protein Length: 379 | Molecular Weight (kDa): 44.568
UniProt ID(s): A8QVP1, A8QVP2, A8QVP6, Q8I1Y5
PDB ID(s): None
Isoelectric Point: 7.29
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR010884 | 6-Cysteine (6-Cys) domain |
| PFam | PF07422 | 6-Cysteine (6-Cys) domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 16313615 | Two proteins with 6-cys motifs are required for malarial parasites to commit toinfection of the hepatocyte. | Ishino T, Chinzei Y, Yuda M | 10.1111/j.1365-2958.2005.04801.x |
| 26612952 | Malaria parasites target the hepatocyte receptor EphA2 for successful hostinfection. | Kaushansky A, Douglass AN, ..., Kappe SH | 10.1126/science.aad3318 |
| 30547015 | The Micronemal Plasmodium Proteins P36 and P52 Act in Concert to Establish theReplication-Permissive Compartment Within Infected Hepatocytes. | Arredondo SA, Swearingen KE, ..., Kappe SHI | 10.3389/fcimb.2018.00413 |
| 38003356 | Carnation Italian Ringspot Virus p36 Expression Induces Mitochondrial Fission andRespiratory Chain Complex Impairment in Yeast | Petrosillo G, De Stradis A, ..., Giannattasio S | 10.3390/ijms242216166 |
| 38168868 | A novel cell biological tool to explain mechanics and dynamics in fission yeast | Rasheed MA, Mohy-Ud-Din R, Anwar T, Faiz M | 10.1002/jobm.202300605 |