About Gene List

PF3D7_0404500 (P52)

Genome location: Pf3D7_04_v3:240,911..242,347(-)

Genome classification: Core

Function and Localization

Product Description: 6-cysteine protein P52

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0046658 anchored component of plasma membrane
Component GO:0009986 cell surface
Component GO:0020009 microneme
Process GO:0044409 entry into host

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.06 0.97
Trophozoite not expressed 0.05 0.97
Schizont not expressed 0.04 0.97
Gametocyte not expressed 0.09 0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0404500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -3.017 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1002200)

  • Relative Growth Rate: 0.95 ± 0.07
  • Confidence: 6.67

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1002200)

Modification: Disrupted | RMgm-5268

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1Y4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215321

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 22 10 32
disruptive 17 34 14 54
missense 14 31 12 44

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 40 25 37
disruptive 30 78 38 113
missense 22 59 33 74

PlasmoDB Total SNPs: 33

Non-coding: 0 | Synonymous: 23 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 478 | Molecular Weight (kDa): 56.287

UniProt ID(s): Q8I1Y4, Q963C0

PDB ID(s): None

Isoelectric Point: 6.96

Protein Domain Annotations:

Source Family ID Description
InterPro IPR010884 6-Cysteine (6-Cys) domain
PFam PF07422 6-Cysteine (6-Cys) domain
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16313615 Two proteins with 6-cys motifs are required for malarial parasites to commit toinfection of the hepatocyte. Ishino T, Chinzei Y, Yuda M 10.1111/j.1365-2958.2005.04801.x
19625622 Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates bydesign. VanBuskirk KM, O'Neill MT, ..., Kappe SH 10.1073/pnas.0906387106