About Gene List

PF3D7_0404600

Genome location: Pf3D7_04_v3:244,986..260,286(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.59 0.77
Trophozoite not expressed 1.42 0.39
Schizont not expressed 0.71 0.65
Gametocyte possibly expressed 1.21 0.42

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0404600

Resistome Missense Mutations: Y2102D, F2128L, K2184I

Resistome Compounds with Missense Mutations: MMV019719, MMV665794, Suloctidil

Resistome # Samples with Disruptive Mutations: 10 (10 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.095 | #Insertions: 16

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1002300)

Modification: Disrupted | RMgm-2708

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532949

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 59 212 123 299
disruptive 261 846 438 895
missense 151 652 362 704

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 98 433 193 331
disruptive 504 1641 660 1505
missense 288 1238 504 949

PlasmoDB Total SNPs: 883

Non-coding: 281 | Synonymous: 309 | Nonsynonymous: 293 | Stop Codon: 0

Protein Information

Protein Length: 4138 | Molecular Weight (kDa): 490.32

UniProt ID(s): Q8I1Y3

PDB ID(s): None

Isoelectric Point: 7.03

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104