About Gene List

PF3D7_0404800

Genome location: Pf3D7_04_v3:264,062..266,503(-)

Genome classification: Core

Function and Localization

Product Description: sporozoite-specific protein S10, putative

SignalP Peptide: MRRYLLITCLFVLCCLKLKHVNF

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring not expressed 0.06 0.97
Trophozoite not expressed 0.06 0.97
Schizont not expressed 0.31 0.81
Gametocyte not expressed 0.15 0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0404800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.299 | #Insertions: 10

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1002500)

  • Relative Growth Rate: 0.99 ± 0.08
  • Confidence: 6.42

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1002500)

Modification: Disrupted | RMgm-4646

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1Y1

"Best" AlphaFill ligand hit: OPE (phosphoric acid mono-(2-amino-ethyl) ester, Local RMSD=2.14) with 2HI2 (Global RMSD=34.60)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533678

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 10 36 24 38
disruptive 33 82 40 120
missense 23 63 29 98

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 16 69 25 44
disruptive 46 178 86 149
missense 29 128 71 96

PlasmoDB Total SNPs: 165

Non-coding: 69 | Synonymous: 22 | Nonsynonymous: 74 | Stop Codon: 0

Protein Information

Protein Length: 567 | Molecular Weight (kDa): 67.078

UniProt ID(s): Q8I1Y1

PDB ID(s): None

Isoelectric Point: 9.81

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
26292257 Discovery of Novel Plasmodium falciparum Pre-Erythrocytic Antigens for VaccineDevelopment. Aguiar JC, Bolton J, ..., Richie TL 10.1371/journal.pone.0136109