PF3D7_0405100 (SEC24B)

Genome location: Pf3D7_04_v3:271,572..277,979(-)

Genome classification: Core

Function and Localization

Product Description: protein transport protein Sec24B, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030127	COPII vesicle coat
Component	GO:0020036	Maurer's cleft
Component	GO:0070971	endoplasmic reticulum exit site
Function	GO:0000149	SNARE binding
Function	GO:0008270	zinc ion binding
Process	GO:0090110	COPII-coated vesicle cargo loading

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.16	0.92
Trophozoite	expressed	0.34	0.79
Schizont	expressed	0.41	0.73
Gametocyte	expressed	0.31	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0405100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.318 | MFS: -2.636 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H489

"Best" AlphaFill ligand hit: COA (coenzyme a, Local RMSD=0.10) with 5K04 (Global RMSD=20.77)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_132992

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	17	82	49	90
disruptive	57	201	78	213
missense	30	144	67	176

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	27	152	57	92
disruptive	108	310	143	304
missense	57	238	112	230

PlasmoDB Total SNPs: 280

Non-coding: 139 | Synonymous: 95 | Nonsynonymous: 46 | Stop Codon: 0

Protein Information

Protein Length: 1350 | Molecular Weight (kDa): 155.937

UniProt ID(s): C0H489, Q8T622

PDB ID(s): None

Isoelectric Point: 6.33

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006896	Sec23/Sec24, trunk domain
InterPro	IPR006900	Sec23/Sec24, helical domain
InterPro	IPR012990	Sec23/Sec24 beta-sandwich
InterPro	IPR036174	Zinc finger, Sec23/Sec24-type superfamily
InterPro	IPR036175	Sec23/Sec24 helical domain superfamily
InterPro	IPR036180	Gelsolin-like domain superfamily
InterPro	IPR036465	von Willebrand factor A-like domain superfamily
PFam	PF04811	Sec23/Sec24, trunk domain
PFam	PF04815	Sec23/Sec24, helical domain
PFam	PF08033	Sec23/Sec24 beta-sandwich
Superfamily	SSF53300	von Willebrand factor A-like domain superfamily
Superfamily	SSF81811	Sec23/Sec24 helical domain superfamily
Superfamily	SSF81995	Gelsolin-like domain superfamily
Superfamily	SSF82754	Zinc finger, Sec23/Sec24-type superfamily
Superfamily	SSF82919

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
31631203	A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum.	Das D, Krishnan SR, Roy A, Bulusu G	10.1039/c9mo00124g