About Gene List

PF3D7_0405200 (CERLI2)

Genome location: Pf3D7_04_v3:277,684..281,983(+)

Genome classification: Core

Function and Localization

Product Description: protein CERLI2

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020008 rhoptry
Component GO:0033016 rhoptry membrane
Process GO:0044409 entry into host

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.08 0.96
Trophozoite expressed 0.21 0.86
Schizont expressed 1.30 0.39
Gametocyte expressed 0.51 0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0405200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.513 | MFS: -2.366 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1002900)

  • Relative Growth Rate: 0.03 ± 0.06
  • Confidence: 6.90

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1X7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_120245

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 14 9 32
disruptive 2 21 18 37
missense 2 21 17 34

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 34 20 22
disruptive 9 50 25 70
missense 6 41 22 58

PlasmoDB Total SNPs: 305

Non-coding: 227 | Synonymous: 55 | Nonsynonymous: 23 | Stop Codon: 0

Protein Information

Protein Length: 579 | Molecular Weight (kDa): 69.103

UniProt ID(s): Q8I1X7, Q95V67

PDB ID(s): None

Isoelectric Point: 5.45

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
35140336 Cell biological analysis reveals an essential role for Pfcerli2 in erythrocyteinvasion by malaria parasites. Liffner B, Balbin JM, ..., Wilson DW 10.1038/s42003-022-03020-9