PF3D7_0405600

Genome location: Pf3D7_04_v3:302,892..305,696(+)

Genome classification: Core

Function and Localization

Product Description: TMEM33 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005783	endoplasmic reticulum
Process	GO:0071786	endoplasmic reticulum tubular network organization
Process	GO:0061024	membrane organization

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.07	0.96
Trophozoite	expressed	0.25	0.84
Schizont	expressed	0.05	0.97
Gametocyte	expressed	0.15	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0405600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -3.091 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1X3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130370

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	27	13	29
disruptive	3	19	10	29
missense	3	19	10	27

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	47	21	24
disruptive	7	45	39	68
missense	5	37	30	51

PlasmoDB Total SNPs: 85

Non-coding: 74 | Synonymous: 7 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 315 | Molecular Weight (kDa): 37.813

UniProt ID(s): Q8I1X3

PDB ID(s): None

Isoelectric Point: 9.9

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR005344	TMEM33/Pom33 family
PFam	PF03661	TMEM33/Pom33 family
Superfamily	N/A	N/A