Product Description: apical sushi protein
SignalP Peptide: MKIIYHILIFLLHYNIIIKA
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0046658 | anchored component of plasma membrane |
| Component | GO:0020009 | microneme |
| Component | GO:1990225 | rhoptry neck |
| Function | GO:0005488 | binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.06 | 0.97 |
| Trophozoite | not expressed | 0.13 | 0.93 |
| Schizont | expressed | 1.96 | 0.31 |
| Gametocyte | not expressed | 0.10 | 0.94 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0405900
Resistome Missense Mutations: M702I
Resistome Compounds with Missense Mutations: Cipargamin/KAE609/NITD609
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.636 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1003600)
Modification: Disrupted | RMgm-2715
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I1W9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 38 | 18 | 43 |
| disruptive | 24 | 107 | 50 | 118 |
| missense | 18 | 91 | 47 | 100 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 71 | 26 | 62 |
| disruptive | 56 | 226 | 88 | 189 |
| missense | 34 | 178 | 70 | 139 |
PlasmoDB Total SNPs: 200
Non-coding: 151 | Synonymous: 20 | Nonsynonymous: 29 | Stop Codon: 0
Protein Length: 731 | Molecular Weight (kDa): 85.461
UniProt ID(s): Q8I1W9
PDB ID(s): None
Isoelectric Point: 5.63
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000436 | Sushi/SCR/CCP domain |
| InterPro | IPR035976 | Sushi/SCR/CCP superfamily |
| PFam | PF00084 | Sushi/SCR/CCP domain |
| Superfamily | SSF57535 | Sushi/SCR/CCP superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 15694487 | A novel Sushi domain-containing protein of Plasmodium falciparum. | O'Keeffe AH, Green JL, Grainger M, Holder AA | 10.1016/j.molbiopara.2004.12.003 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 16603573 | Identification and stoichiometry of glycosylphosphatidylinositol-anchoredmembrane proteins of the human malaria parasite Plasmodium falciparum. | Gilson PR, Nebl T, ..., Crabb BS | 10.1074/mcp.M600035-MCP200 |
| 20540969 | Localization of apical sushi protein in Plasmodium falciparum merozoites. | Srivastava A, Singh S, ..., Chitnis CE | 10.1016/j.molbiopara.2010.06.003 |