About Gene List

PF3D7_0406000

Genome location: Pf3D7_04_v3:320,299..322,945(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.18 0.91
Trophozoite expressed 0.48 0.71
Schizont expressed 0.79 0.56
Gametocyte possibly expressed 0.40 0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0406000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.165 | MFS: -2.811 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1003700)

  • Relative Growth Rate: 0.20 ± 0.19
  • Confidence: 4.73

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I1W8

"Best" AlphaFill ligand hit: UDP (uridine-5'-diphosphate, Local RMSD=2.96) with 5GGI (Global RMSD=18.76)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139493

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 17 17 28
disruptive 18 68 45 83
missense 11 44 39 62

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 38 28 29
disruptive 31 160 64 158
missense 13 109 47 92

PlasmoDB Total SNPs: 126

Non-coding: 87 | Synonymous: 21 | Nonsynonymous: 18 | Stop Codon: 0

Protein Information

Protein Length: 508 | Molecular Weight (kDa): 60.614

UniProt ID(s): Q8I1W8

PDB ID(s): None

Isoelectric Point: 8.96

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
33823306 Conserved Plasmodium Protein (PF3D7_0406000) of Unknown Function: In-silicoAnalysis and Cellular Localization. Pandey I, Quadiri A, ..., Das A 10.1016/j.meegid.2021.104848