Product Description: parasitophorous vacuole membrane protein S16
SignalP Peptide: MNIRKFIPSLALMLIFFAFANLVLS
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0016021 | integral component of membrane |
| Component | GO:0016020 | membrane |
| Component | GO:0005634 | nucleus |
| Component | GO:0020005 | symbiont-containing vacuole membrane |
| Process | GO:0009410 | response to xenobiotic stimulus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.23 | 0.91 |
| Trophozoite | expressed | 0.24 | 0.89 |
| Schizont | expressed | 0.17 | 0.91 |
| Gametocyte | expressed | 4.19 | 0.03 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0406200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.158 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1003900)
Modification: Tagged | RMgm-4409
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q6ZMA7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 134
Non-coding: 125 | Synonymous: 3 | Nonsynonymous: 5 | Stop Codon: 1
Protein Length: 157 | Molecular Weight (kDa): 16.626
PDB ID(s): None
Isoelectric Point: 5.92
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006389 | Early transcribed membrane protein (ETRAMP) |
| PFam | PF09716 | Early transcribed membrane protein (ETRAMP) |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 2038355 | A novel protein antigen of the malaria parasite Plasmodium falciparum, located onthe surface of gametes and sporozoites. | Moelans II, Meis JF, ..., Schoenmakers JG | 10.1016/0166-6851(91)90086-l |
| 7935618 | Cellular location and temporal expression of the Plasmodium falciparum sexualstage antigen Pfs16. | Bruce MC, Carter RN, ..., Carter R | 10.1016/0166-6851(94)90111-2 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 14698439 | Functional analysis of Plasmodium falciparum parasitophorous vacuole membraneprotein (Pfs16) during gametocytogenesis and gametogenesis by targeted genedisruption. | Kongkasuriyachai D, Fujioka H, Kumar N | 10.1016/j.molbiopara.2003.10.014 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 36409095 | Plasmodium falciparum Sexual Commitment Rate Variation among Clinical Isolatesand Diverse Laboratory-Adapted Lines | Stewart LB, Freville A, ..., Conway DJ | 10.1128/spectrum.02234-22 |
| 37196765 | Plasmodium parasitophorous vacuole membrane protein Pfs16 promotes malariatransmission by silencing mosquito immunity | Ramelow J, Keleta Y, ..., Li J | 10.1016/j.jbc.2023.104824 |
| 36715290 | A novel class of sulphonamides potently block malaria transmission by targeting aPlasmodium vacuole membrane protein | Yahiya S, Saunders CN, ..., Baum J | 10.1242/dmm.049950 |