PF3D7_0406500

Genome location: Pf3D7_04_v3:333,546..345,127(-)

Genome classification: Core

Function and Localization

Product Description: NYN domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.97	0.33
Trophozoite	expressed	1.72	0.28
Schizont	expressed	1.67	0.31
Gametocyte	expressed	1.85	0.25

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0406500

Resistome Missense Mutations: S446F

Resistome Compounds with Missense Mutations: 3-Hydroxypropanamidine 22

Resistome # Samples with Disruptive Mutations: 2 (1 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.598 | #Insertions: 20

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_111401

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	35	109	57	133
disruptive	148	392	203	447
missense	76	265	158	310

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	47	196	92	130
disruptive	262	705	301	552
missense	121	467	233	367

PlasmoDB Total SNPs: 770

Non-coding: 93 | Synonymous: 318 | Nonsynonymous: 359 | Stop Codon: 0

Protein Information

Protein Length: 3211 | Molecular Weight (kDa): 383.846

UniProt ID(s): C0H491

PDB ID(s): None

Isoelectric Point: 8.88

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF141571	N/A

PMID	Title	Authors	DOI/Link
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104